Normal blood pressure during the day and elevated at night suggests the presence of hypertension in the patient. Treatment of nighttime hypertension includes oral antihypertensive drugs, staggering the time of medication, and switching to longer-acting antihypertensive drugs. 1. Commonly used antihypertensive drugs include angiotensin-converting enzyme inhibitors, angiotensin 2 receptor antagonists, diuretics, beta-blockers, and calcium antagonists. (1) Angiotensin-converting enzyme inhibitors and angiotensin 2 receptor antagonists can inhibit the renin-angiotensin system, which can relax blood vessels and reduce sodium retention in the body, and play a role in lowering the blood pressure, and the common medicines are chlorthalidomide, captopril and so on. (2) Diuretics can promote the body’s drainage, sodium, is more commonly used antihypertensive drugs, representative drugs are hydrochlorothiazide, spironolactone, furosemide and so on. (3) β-blockers are mainly used to reduce blood pressure by slowing down the heart rate and lowering myocardial oxygen consumption, which is suitable for patients with fast heart rate, and the representative drugs are metoprolol, bisoprolol, atenolol and so on. (4) Calcium antagonist mechanism is to block the calcium channel on the vascular smooth muscle, so as to dilate the blood vessels to reduce blood pressure, the representative drugs are nifedipine, amlodipine, lasidipine and so on. 2. Normal blood pressure during the day and high blood pressure at night suggests that the blood pressure has lost its circadian rhythm, so it is recommended to take antihypertensive drugs in the afternoon or evening, and test the changes in blood pressure for 24 hours if necessary to understand the fluctuation of blood pressure and adjust the time of medication in a timely manner. 3. Patients with high blood pressure at night are preferred to use long-acting antihypertensive drugs, which can continue to lower blood pressure smoothly for 24 hours and can control blood pressure better. Antihypertensive drugs are usually used in combination, it is recommended to go to the hospital in time, please follow the doctor’s instructions for medication.