Scleroderma does not have the best treatment plan, due to individual differences, the treatment of scleroderma should be based on the patient’s condition to choose individualized treatment methods, clinical treatment methods commonly used are general treatment, drug treatment and surgical treatment. 1. General treatment: patients need to quit smoking and drinking, avoid emotional stress, pay attention to personal protection, pay attention to warm limbs. Actively cooperate with physical therapy, such as heat therapy and muscle massage. 2. Drug therapy: glucocorticoid therapy, for early scleroderma, inflammatory complications and interstitial lung disease is effective, but the drug does not stop the progress of the disease. Immunosuppressants, commonly used drugs such as merti-macrolide, cyclophosphamide, azathioprine, etc. These drugs are easy to inhibit the immune function of the patient’s body, and need to be evaluated by a doctor before using the drug. Vasodilators, commonly used drugs are nifedipine, aspirin, prostacyclin, etc. These drugs can treat scleroderma limb vasculopathy. Anti-fibrotic treatment, there is no effective reversal of the fibrotic process of drugs, but there are some drugs with potential anti-fibrotic effect has been used outside the indications, such as D-penicillamine, imatinib and so on. 3. Surgical treatment: If the patient’s condition is more serious, and there is ulceration or even necrosis of the limbs, then surgical amputation is needed. The above drugs must be used under the guidance of a doctor, do not use privately. It is recommended that patients with scleroderma go to the rheumatology and immunology department in time and follow the doctor’s instructions for treatment.