Adult STILL disease is a group of clinical syndromes presenting with high fever, transient rash, arthritis/arthralgia, sore throat, and elevated white blood cell count. Currently, NSAIDs, glucocorticoids, immunosuppressants, biologics, and other drugs are the main clinical treatments.
1. Non-steroidal anti-inflammatory drugs: Non-steroidal anti-inflammatory drugs, such as celecoxib and ibuprofen, are preferred for mild patients, some of whom can be relieved and have a good prognosis.
2. Glucocorticosteroids: Glucocorticosteroids are the first choice for the treatment of this disease, commonly used drugs include methylprednisolone, prednisone and so on. For patients who are not well treated with NSAIDs, with systemic damage and recurrence, this kind of drugs can be applied.
3. Immunosuppressant: Immunosuppressant and glucocorticoid can be used in combination to control the disease and help reduce the dosage of glucocorticoid. It has been confirmed that methotrexate can control the disease. Cyclophosphamide, cyclosporine, azathioprine, etc. also have different efficacy.
4. Biological agents: Some patients with severe, relapsed and refractory STILL can choose to apply TNF-α inhibitors such as infliximab, IL-6 antagonists such as tolizumab and other biologics, which can effectively relieve clinical symptoms.
5. Other drugs: patients with serious conditions can also apply high-dose immunoglobulin intravenous injection, plasma replacement.
Adult Still’s disease treatment drugs should be based on the patient’s specific condition, diagnosed adult Still’s disease is recommended under the guidance of a professional doctor standardized treatment.