Interferon is the earliest antiviral drug, his dominant position in hepatitis C is currently no drug can shake, interferon combined with ribavirin is the international common anti-HCV program, especially pegylated interferon combined with ribavirin, for refractory hepatitis C, some protease inhibitors and other will be listed, but most of them should also be combined with interferon. Although interferon against hepatitis B has been challenged by nucleoside analogues in recent years, it still has its irreplaceable role, first of all, his role is multifaceted, including the role of immune regulation, direct antiviral effect, anti-fibrotic effect, and some experts believe that it can reduce the occurrence of liver cancer to some extent. The second is that his seroconversion rate of HBeAg/anti-KBe and the disappearance rate of HBsAg are incomparable to nucleoside analogues, for young people, there is no contraindication to the application of interferon should first use interferon treatment, if there is no effect or itself due to age, side effects, work, life and other factors can not apply interferon can consider nucleoside analogues, the biggest disadvantage of interferon is that the rate of HBVDNA conversion The biggest disadvantage of interferon is that the rate of HBVDNA conversion, the speed of conversion is obviously inferior to that of nucleoside analogues, and the side effects are obvious during the application period, to strengthen the detection.