Myeloma can be clearly diagnosed through relevant laboratory tests and imaging tests, and daily care should include psychological counseling in addition to diet and exercise. 1. Laboratory tests related to myeloma (1) Blood picture: it is often manifested as normocytic normochromic anemia. (2) Bone marrow: there is often abnormal proliferation of plasma cells in bone marrow. (3) Identification of blood M protein: the presence of M protein in serum is a major feature of this disease. (4) Urine examination: proteinuria, hematuria, and tubular urine are often seen. (5) Imaging examination: X-ray, CT, MRI, PET/CT, etc. Osteolytic damage of varying sizes is often shown on X-ray, and there may be pathological fracture and osteoporosis, etc. 2. Daily care of myeloma: on diet, it is recommended to consume easily digestible food containing high protein and vitamin, drink more water, and low-sodium and low-protein diet in case of renal insufficiency; in general, there can be moderate exercise, and it is recommended to have bed rest for patients with bone destruction; if bone pain is serious, it is recommended to take appropriate amount of analgesic such as ibuprofen according to doctors’ instructions. In addition, for myeloma patients, they should channel their emotions in time, relieve their pressure, actively cooperate with physicians for treatment, and go to the hospital for regular review.