High mean red blood cell volume may be physiologically elevated or pathologically elevated, such as megaloblastic anemia, other diseases, and so on. 1. Physiological elevation: if it is a newborn baby or during pregnancy, etc., it may lead to high average red blood cell volume. 2. Megaloblastic anemia: due to the lack of sufficient folic acid and vitamin B12 in the patient, resulting in megaloblastic anemia, so the patient’s average red blood cell volume is high, accompanied by low hemoglobin. 3. Other diseases: such as hemolytic anemia, anemia of liver disease, myelodysplastic syndrome and so on. If the average red blood cell volume is high for a long time, you should go to the hospital in time and ask the doctor to improve the examination and carry out standardized treatment.