There is nothing particularly characteristic about swollen lymph nodes in syphilis. Enlargement of the lymph nodes in stage I syphilis usually occurs 1-2 weeks after the appearance of the noma, either unilaterally in the groin or in the lymph nodes near the site of the noma. There is marked enlargement of the lymph nodes, the surface does not become red and swollen and broken, the patient does not experience pain or tenderness in the lymph nodes, and it takes several months for the swelling to subside. If a lymph node puncture is done at this time, the presence of large numbers of syphilis spirochetes can be detected. In stage II syphilis, multiple sclerosing lymphadenitis, which occurs in more than 50% of cases, the lymph nodes of the whole body will be enlarged, but there is still no pain or tenderness, and the surface will not be red, swollen or ulcerated.