Syphilis is a chronic infectious disease caused by the pallid spirochete, mainly sexually transmitted diseases. Different stages of syphilis have different clinical manifestations. Early syphilis is characterized by a hard chancre, which appears as a round or oval ulcer with a clear border on the genital area of the patient, elevated above the surface of the skin, with a relatively clean wound, but with increased secretion in the case of secondary infections, and in some patients there is a subsequent enlargement of the lymph nodes, with the inguinal lymph nodes being the main manifestation. Syphilis will then present with systemic symptoms and a typical syphilitic rash, with systemic symptoms manifesting in the skin, mucous membranes, bones, internal organs, cardiovascular and neurological systems. Systemic symptoms usually occur before the appearance of the rash, and in advanced syphilis, the main manifestations are dendritic swelling, cardiac and neurological invasion.