The early signs and symptoms of dry syndrome are mainly dry mouth and caries and dry eyes. Dry syndrome is a chronic immune disease that attacks exocrine glands and tissues and organs throughout the body. Salivary glands, lacrimal glands, and any organ in the body can be involved. 1. Dry mouth and dental caries: There are no conscious symptoms despite the decrease in saliva volume. Patients with dry mouth are self-conscious of dry mouth, which often extends to the pharynx, and in severe cases, they often drink frequently and must be brought down with water when eating solid food. About 50% of patients with teeth gradually blackened, powder or small pieces off, leaving only the residual roots to become “rampant teeth”, is one of the characteristics of dry mouth syndrome. 2. Dry eyes: dryness of the eyes, “foreign body sensation”, “gravel sensation”, burning sensation caused by reduced secretion of the lacrimal gland. An early manifestation of dry eye is the patient’s inability to tolerate wearing contact lenses. Other common symptoms include photophobia, redness, and eye fatigue. When these symptoms occur, patients should seek medical attention from a rheumatologist and be treated under a doctor’s supervision.