OBJECTIVE: To investigate the care of radiofrequency ablation (RFA) of lung cancer with CT-guided percutaneous lung puncture. METHODS: To cooperate and care for 24 patients with lung cancer who underwent CT-guided percutaneous pulmonary puncture RFA. RESULTS: The procedure went smoothly in this group of patients, and three of them developed pneumothorax, which disappeared after treatment, and the procedure was successful in all cases. CONCLUSION: This procedure is safe and effective, and active cooperation and nursing care can help the successful completion of the operation and early detection and management of complications.