Biologics for the treatment of ankylosing spondylitis range in price from $180 to $3,000 per drug, depending on the manufacturer, variety, and dosage form. Common biological agents for the treatment of ankylosing spondylitis include recombinant type II tumor necrosis factor receptor antibody fusion protein, infliximab, adalimumab, etanercept, etc. The price of each drug ranges from $180 to $3,000 depending on the manufacturer, variety, dosage form, and region. Drugs for ankylosing spondylitis, in addition to biologics and traditional synthetic anti-rheumatic drugs such as sulfasalazine, can play a role in slowing down the progression of the disease and alleviating the clinical symptoms of patients, according to the patient’s condition, the development of a specific treatment program. Drugs should be used under the guidance of a physician, and it is recommended that patients with ankylosing spondylitis who need to use biologics for treatment go to the rheumatology and immunology department of a regular hospital for relevant consultation.