Many people know that obesity leads to diabetes, that obesity also induces cancer, and that pancreatic cancer is a major contributor to diabetes. In fact, the association between the three, obesity, diabetes and pancreatic cancer, has been confirmed by many credible data. Body mass index (BMI ≥ 35, obese) has a significantly increased risk of pancreatic cancer compared to normal weight people (BMI: 18.5-24.9). In addition, some studies claim that every 5 kg/m increase in BMI increases the risk of pancreatic cancer by 12%. Similarly, diabetes and pancreatic cancer risk have been studied epidemiologically in recent years. One study concluded that 34% of patients with pancreatic cancer induced diabetes mellitus. Thus, the onset is related to the course of diabetes when it is an important factor in the risk of developing pancreatic cancer: deceased pancreatic cancer patients usually have an associated history of diabetes. Interestingly, however, it seems that the longer the duration of diabetes, the lower the probability of incidence seems to be. In many developed countries, the increased incidence of obesity and diabetes is also positively associated with the incidence of pancreatic cancer. So, it is natural to wonder if we can screen for pancreatic cancer by the biological markers involved. However, we are currently unsure of the biological mechanisms between them. Why does obesity cause cancer? Obesity is not a direct cancer-causing factor and the exact mechanism by which it induces the development of cancer is not known. However, it is not difficult to understand the correlation by looking at the lifestyle habits of fat people. Obese patients tend to prefer foods high in calories, animal fat, trans fatty acids and refined carbohydrates, while the intake of dietary fiber, whole grain carbohydrates, vegetables and fruits is insufficient. Such a diet will make the body’s hormone imbalance. This is because the adipose tissue in obese patients will secrete too much aromatase, speeding up the conversion of estrogen precursors to estradiol and raising serum estradiol levels. High estrogen levels are associated with the development of many types of cancer, such as breast and endometrial cancers. Also, overweight and obesity will directly lead to insulin resistance, thus causing hyperinsulinemia, which affects the regulatory cycle of cell growth and accelerates genetic mutations and the development of cancer. Obesity or overweight is certainly not good for health, but it is not the slimmer the better. The most appropriate BMI is 22, below 18 is also detrimental to health and can increase the risk of cancer, such as lung cancer. In terms of cancer prevention, weight control is a good measure. Studies have shown that the relative risk of breast cancer and colorectal cancer can be reduced by 50% in people who actively reduce their weight. Can I lose weight with surgery? The full name is laparoscopic gastric reduction surgery, also known as sleeve gastrectomy. The principle of gastric reduction surgery is to use a laparoscope to cut out the large curve of the stomach vertically so that a small stomach sac of about 150cc is formed, which can hold about 4-5 ounces of food. It has the benefit of not requiring a foreign object to be placed in the body and the procedure is remarkably effective for weight loss. Weight loss surgery can lose 60-80% of your excess weight, and the results will be even better if your post-operative diet and exercise habits are well coordinated with the support and assistance of a professional health manager.