Children born after the 1980s, I’m afraid they’ve never heard of the saying “squash and vegetables, two meals thin, one dry”. The only foods that leave a deep impression in their minds may be such high-energy foods as chocolate and McDonald’s. But they may not know that a hamburger, a packet of fries and a cup of coffee are not enough. But they may not know that a hamburger, a package of fries and a milkshake together contain about 4,000 kilojoules (about 956 kcal) of energy, equivalent to more than half of the total daily energy needs of a normal adult, if at the same time a fried chicken leg, the body’s energy intake is even more significant. Even for those adults who know these past events, with the improvement of living standards, the life of a meat and wine every day is not too difficult for everyone. So to speak, the quality of life has improved, a little carelessness, and with it, the downside of over-nutrition. Obesity: External causes are dominated by too much diet and too little activity. Caloric intake more than caloric consumption, so that fat synthesis increase is the material basis of obesity. Internal because of fat metabolism disorder and cause obesity. 1, genetic factors human simple obesity onset has a certain genetic background. Some studies think, one of the two parents is obese, its children obesity rate is about 50%; Both parents are obese, its children obesity rate rises to 80%. Human obesity is generally considered to be polygenic inheritance, genetics plays a susceptible role in its development. The formation of obesity also with the way of life behavior, food intake behavior, hobbies, climate and the interaction of psychosocial factors. 2, endocrine factors Many hormones such as thyroxine, insulin, glucocorticoids, etc. can regulate feeding, so it is presumed that these hormones may be involved in the pathogenesis of simple obesity. Obese people to insulin resistance and lead to hyperinsulinemia, and hyperinsulinemia can make insulin receptor down regulation and increase insulin resistance, thus forming a vicious circle. Increased insulin secretion can stimulate increased food intake and at the same time inhibit lipolysis, thus causing fat accumulation in the body. Sex hormones may play a role in the pathogenesis of simple obesity. Gastric bypass surgery for weight loss: Gastric bypass surgery refers to a series of similar surgical procedures used to treat obesity, with the following common features: the surgery first divides the stomach into two parts, the smaller upper part, and the larger lower part, then truncates the small intestine, rearranges the position of the small intestine, changes the pathway of food through the digestive tract, slows gastric emptying, shortens the small intestine, and reduces absorption. By 2005 surgeons had developed several different alignment options, forming several branches of gastric bypass surgery. According to 2008 data from the National Center for Health, gastric bypass surgery has replaced gastric reduction surgery as the most popular bariatric procedure in the United States since 2000, with approximately 100,000 cases performed each year. Gastric bypass efficacy: Studies have shown that patients who underwent bariatric and diabetic surgery were able to achieve complete blood glucose remission in patients with type 2 diabetes compared to those who only underwent traditional medication. Two years after undergoing gastric bypass, patients had a 75% remission rate of diabetes. Diabetes remission was defined as glycosylated hemoglobin <6.5% and no medications. In addition, weight loss with diabetes surgery significantly addresses or improves type 2 diabetes and other obesity comorbidities. Studies have shown that weight loss and diabetes surgery can resolve or improve diabetes in 86% of patients, improve hyperlipidemia in 70% or more of patients, resolve or improve hypertension in 78.5% of patients, and also en able to resolve sleep apnea in 85.7% of patients Is it possible for all obese people? Its indications:1 Obese patients with BMI greater than 32, or BMI greater than 28 but with type 2 diabetes, diabetic patients must have a certain residual function of the pancreas, c peptide must be higher than half of the lowest value of the normal range.2 Obese patients with poor non-surgical results and easy to rebound.