The relief of breath-holding in advanced lung cancer depends on the cause of breath-holding: if it is combined with a large amount of pleural effusion causing chest compression and difficulty in breathing, adequate puncture and drainage can be done for pleural effusion, and then chemotherapy drugs such as cisplatin, bleomycin, interferon or anti-tumor angiogenic drugs can be infused into the chest cavity, which can help relieve the symptoms of chest tightness and breath-holding. If lung cancer combined with obstructive pneumonia causes breathlessness, the main treatment is radical radiotherapy or simultaneous radiotherapy or chemotherapy for lung cancer, which helps to relieve the symptoms of chest tightness and breathlessness. For other rare causes, such as pulmonary embolism or coexisting coronary heart disease, anticoagulation therapy can be used to deal with pulmonary embolism or coronary heart disease. In conclusion, breathlessness in advanced lung cancer should be dealt with according to different causes.