Low back pain after waking up is a very common clinical manifestation in the clinic. If you have back pain after waking up from sleep, first, consider lumbar disc herniation. Because patients with lumbar disc herniation get good rest when they sleep, they will not have lumbar pain, but when they change from sleep state to normal activity state, the muscles of the lumbar region and the joints of the lumbar vertebrae all undergo some changes, and the nerves in the spinal canal may be harassed, so they produce lumbar pain. Second, consider chronic soft tissue lesions of the lumbar spine such as lumbar muscle strain and lumbar dorsal myelitis. In the resting state, the lumbar muscles are relaxed and no pain occurs, but once the activity is done, pain may occur, so consider whether there are some soft tissue diseases of the lumbar back. Another type of disease that cannot be ignored is ankylosing spondylitis. In patients with ankylosing spondylitis, the clinical manifestations are very typical of pain in the low back after activity, and also after the transition from rest to activity, that is, from sleep to wakefulness. Therefore, if low back pain occurs after waking up from sleep, consider lumbar spine soft tissue diseases, diseases of the lumbar spine itself, or immune system diseases, such as ankylosing spondylitis. The above content is for reference only. Please refer to the doctor’s face-to-face guidance for specific medication and treatment.