Acne inflammation into a pustule with hard lumps is considered to be the development of acne to grade Ⅲ, Ⅳ, can take medication, physical therapy. 1. medication: acne inflammation into pustules with hard lumps need to be under the guidance of the doctor with retinoic acid cream, isotretinoin gel and other retinoic acid drugs. In addition, patients can also follow the doctor’s instructions with fusidic acid cream, mupirocin ointment and other antibiotic ointment. In addition, the body androgen abnormal patients can also follow the doctor’s instructions with compound ethinyl estradiol tablets, compound norethindrone tablets and other contraceptives. 2. Physical therapy: patients with acne inflammation pustules with hard lumps need to take photodynamic therapy treatment, which is conducive to reducing the inflammatory response and destruction of Propionibacterium acnes. In addition, the patient usually need to keep the face clean, diet should eat less fried chicken, meat and other greasy food, as well as candy, candies and other high-sugar food. It is recommended that patients with acne inflammation into a pustule with hard lumps need to consult a doctor in a timely manner, under the guidance of the doctor to choose the appropriate measures for treatment. The above drugs need to be used in accordance with medical advice.