Eyes always want to close, if refractive error, old eyesight and other causes of visual fatigue caused by refractive error can be corrected, and dry eye caused by patients can follow the doctor’s instructions to use artificial tears treatment to relieve eye discomfort. Eyes always want to close up more reasons, mostly related to visual fatigue. Patients first need to improve optometry and other ancillary tests to clarify the diagnosis, for refractive error or old eyesight and other causes of visual fatigue, patients want to close their eyes, can be corrected by refractive error and adjust the brightness of the eye environment, to relieve visual fatigue to achieve the purpose of improving the patient’s discomfort. When the patient has dry eye, because of the tear film stability or tear kinetic abnormality, the patient’s eye surface lacks of tear moisturizing, eye irritation can occur, so there may be the feeling of always wanting to close the eyes, the patient can follow the doctor’s instructions to use sodium vitreous acid eye drops and other artificial tears for alternative treatment, to alleviate the discomfort of the eyes. It is recommended that patients who always want to close their eyes should consult a doctor in time to assess their condition and follow the doctor’s instructions for treatment.