Neonatal jaundice can be seen in hemolytic jaundice, infection, breast milk jaundice, etc. Whether the value of jaundice will increase after taking medication needs to be analyzed specifically, such as hemolytic jaundice, the effect of oral medication is generally poor, and phototherapy or gammaglobulin is needed to treat the disease. 1.hemolytic jaundice: mother and child blood group incompatibility caused by homozygous immune hemolysis, the severity of the disease and the degree of hemolysis related to the clinical jaundice, often in the first 24 hours of life and rapidly aggravated, can be accompanied by anemia. For this kind of children, the effect of oral medication to reduce the yellow is not good, and the treatment requires the use of phototherapy and gammaglobulin and other treatments. 2. Infection: Umbilical cord infection or sepsis can also occur, and jaundice often appears to recur. These babies need to be evaluated by a specialist to control the infection. Oral anti-infective drugs (e.g., cefdinir) can be effective in mild cases, but in severe cases, intravenous infusion of anti-infective drugs such as cefuroxime is usually needed. Oral medication alone may not be effective in reducing jaundice, and jaundice may become elevated. 3. Breast milk jaundice: occurs in breastfeeding babies, the diagnosis needs to be excluded from causing jaundice of other diseases, such babies jaundice value has not yet reached the standard of phototherapeutic intervention, general suspension of breast milk jaundice can gradually subside. 4. Other: such as hypothyroidism, jaundice can also occur, for such babies to take medicine to reduce the yellow effect is not good, need to use thyroxine under the guidance of a physician for the cause of the treatment. It is recommended to actively consult a specialist physician to assess the judgment and give appropriate intervention. The above medications should be taken in accordance with medical advice.