Velia is the trade name, generic name of Candesartan. Baxin Tong is the trade name, generic name of nifedipine controlled release tablets, the two drugs have different mechanisms of action can be used at the same time, there is no contraindication. 1. Candesartan’s main effect is to inhibit angiotensin II receptors, the main indication is hypertension. Nifedipine controlled-release tablets can inhibit calcium ion inward flow, through the dilation of blood vessels to reduce blood pressure. Combining the two drugs at the same time has a synergistic effect on lowering blood pressure, and there is no significant increase in adverse effects, and there is no contraindication to the use of the two drugs. 2. The adverse reactions of Candesartan include laryngeal edema, dizziness, syncope, elevation of blood potassium, transaminase abnormality, nausea and vomiting. The adverse reactions of nifedipine controlled-release tablets include lower limb edema, constipation, tachycardia, flushing and so on. 3. Candesartan is prohibited in patients who are allergic to the drug components, lactating pregnant women, and patients with severe hepatic or renal insufficiency. Nifedipine controlled-release tablets are contraindicated in patients who are allergic to the components of the drug, cardiogenic shock, severe aortic stenosis, or taking rifampicin. When taking candesartan and nifedipine controlled-release tablets orally to lower blood pressure, use the medication under the guidance of a physician and choose the appropriate dose.