Noninvasive chromosome 16 preference is not recommended, and chromosome 16 preference can lead to adverse pregnancy outcomes such as miscarriage. Chromosome 16 has a higher probability of chromosomal nondisjunction leading to trisomy, the consequences of which are spontaneous abortion in early pregnancy, or chromosome 16 trisomy chimerism, uniparental dichorionicity in the fetus or placenta. Chromosome 16 trisomy usually results in early pregnancy embryonic arrest and is the most common chromosomal abnormality in early pregnancy spontaneous abortions.Chromosome 16 trisomy is lethal, and to date there are no cases of live births or adults with non-chimeric chromosome 16 and no treatment is available. Chromosome 16 trisomy forms either a chromosome 16 trisomy chimera or a uniparental dystrophy through a trisomy self-rescue mechanism, both of which may result in fetuses with congenital cardiovascular, skeletal, and genitourinary structural malformations, as well as abnormal facial features. Therefore, it is not recommended to have a noninvasive chromosome 16 excess.