Penicillins are generally preferred for the treatment of syphilis, such as aqueous penicillin, procaine penicillin, benzylpenicillin which are commonly used in clinical practice, and tetracycline or erythromycin can also be used for patients allergic to penicillin. Most of the syphilis can be cured, but the syphilis treatment time is relatively long, from the beginning of receiving treatment, generally need patients to continuously observe 2-3 years, the first year after the formal treatment, every 3 months will need to be regularly serological review, to observe the condition of the treatment. If the control is relatively good, the review will be conducted every 6 months in the 2nd-3rd year. If in the process of review, the results of 3-4 consecutive tests are normal, then the syphilis can be judged as cured, the patient can stop the drug, so syphilis once the treatment must be adhered to.