The acne-like bumps on the thighs are considered to be folliculitis or keratosis pilaris, and should be promptly consulted to find out the cause of the disease. 1. Folliculitis: folliculitis is mostly caused by bacterial infections, which can lead to acne-like bumps on the surface of the thighs, you can apply mupirocin ointment under the guidance of a doctor for treatment, and in severe cases, you can also take cephalosporin anti-inflammatory drugs for treatment. 2. Keratosis pilaris: a chronic follicular keratosis pilaris. The etiology and pathogenesis are unknown, and may be related to autosomal dominant inheritance, vitamin A deficiency, and metabolic disorders. It can lead to follicular papules on the legs with light brown keratin plugs at the tips, leaving small funnel-shaped depressions when the plugs are peeled off. In addition to these factors, do not rule out that there are other causes, it is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease, and follow the doctor’s instructions for standardized treatment.