Pain and discomfort in the chest after falling asleep at night is common in two main categories of diseases. The first category of diseases, mainly digestive diseases, including peptic ulcer, such as gastric ulcer and duodenal bulbous ulcer subacromial pain, involving chest pain and discomfort, or acute stone cholecystitis, the right upper abdominal pain and discomfort, which manifests itself in the chest pain and discomfort, you need to further abdominal ultrasound, or gastroscopy, diagnosis is clear, peptic ulcer is usually treated with antiulcer therapy, while for gallbladder stones patients usually need to perform cholecystectomy. When the diagnosis is clear, peptic ulcers are usually treated with anti-ulcer therapy, while gallbladder stones are usually treated with cholecystectomy. The second category of diseases, mainly cardiopulmonary system diseases, such as various lung diseases, pneumonia, pleural effusion or tuberculosis pleurisy caused by chest pain and discomfort in the chest, need to be further chest radiography, or chest CT examination, diagnosis is clear and need anti-inflammatory treatment, or even anti-tuberculosis drug treatment. Heart disease is mainly due to myocardial ischemia caused by coronary artery stenosis, usually need to carry out electrocardiogram and myocardial enzyme examination, if necessary, coronary angiography, and often need to carry out stenting intervention for patients with serious symptoms.