There are three main possibilities for chest pain at night: first, physiological reasons, sleep due to prone position or lateral position can compress the local chest muscles, resulting in impaired blood circulation, lactic acid and other metabolites accumulation of chest pain and intolerable discomfort. Second, reflux esophagitis, sleeping due to the pressure drop in the esophagus, gastric acid reflux into the esophagus increases the appearance of post-sternal pressure pain, can be accompanied by belching and acid reflux discomfort. Third, intercostal neuralgia is caused by nerve dysfunction, sleep due to the vagus nerve excitation can cause chest pain and discomfort, can be relieved after rest. Sleeping at night chest pain is mostly caused by benign diseases, will not cause serious consequences, if the pain persistent aggravation, it is recommended to go to the regular hospital in a timely manner, to clarify the cause of pain, and actively cooperate with the specialist treatment.