The degree of harm of taking a daily allopurinol can not be generalized, need to be decided according to the specific situation of the patient, taking allopurinol common hazards are gastrointestinal reactions, skin rash, leukopenia and so on. Allopurinol is a kind of inhibition of uric acid production so as to reduce the concentration of blood uric acid in the patient’s body of the drug, used in the treatment of primary and secondary hyperuricemia; recurrent or chronic gout; gout stone; uric acid kidney stones and (or) uric acid nephropathy; hyperuricemia with renal insufficiency. The common drug specification is 0.1g/tablet, the initial dose for adults is 50 mg once a day, 1~2 times a day, and it can be increased by 50~100 mg every week to 200~300 mg a day, which is taken in 2~3 times. One allopurinol tablet per day is within the recommended dose. Common adverse reactions include gastrointestinal reactions, skin rashes, leukopenia, etc. The degree of harm that may be associated with the administration of allopurinol varies depending on the patient’s specific condition and cannot be generalized. It is contraindicated in cases of hypersensitivity to the components of the drug, markedly low blood counts and severe hepatic or renal insufficiency. Pay attention to the use of the drug after the disappearance of acute inflammatory symptoms of gouty arthritis, and drink more water during the use of the drug to facilitate the excretion of uric acid. Drugs need to be used under the guidance of a physician, it is recommended that patients who need to take allopurinol treatment to the relevant departments of the regular hospital for detailed consultation.