The order of hormone supplementation for anterior pituitary hypopituitarism is glucocorticoids, thyroid hormones, and gonadal hormones. Any disease that causes destruction of the hypothalamus or anterior pituitary gland may cause anterior pituitary hypopituitarism, and anterior pituitary hypopituitarism will cause a decrease in adrenal, gonadal, and thyroid functions. The principle of hormone replacement therapy is to make up for what is lacking and how much is lacking, and the process of supplementing hormones has a certain sequence, the first thing that needs to be supplemented is glucocorticoids, then thyroid hormones, and finally gonadal hormones; if thyroid hormones are supplemented first, it will lead to adrenal crisis due to the increase in metabolic rate. Patients diagnosed with anterior pituitary hypopituitarism should actively cooperate with their doctors.