The main side effects of long-term glucocorticoid use. First of all, long-term use can cause disorders of electrolytes such as water, sodium and potassium, as well as metabolic disorders such as sugar, protein and fat. Common clinical manifestations may include centripetal obesity, full-moon face, buffalo back, acne on the face, and hairiness on the body. Blood tests may show hypernatremia and hypokalemia, and may cause metabolic syndromes such as hypertension, edema, hyperlipidemia, and diabetes mellitus. Long-term use of large doses of glucocorticoids may also cause osteoporosis and even necrosis of the femoral head. Long-term application of hormones can weaken the body’s resistance, hinder tissue repair and retard tissue. If glucocorticoids are used for a long time during childhood, it may inhibit growth and development.