Colonic melioidosis is a condition in which a colonoscopy reveals serpiginous changes or pigmentation of the colon, mostly called colonic melioidosis. Colonic melanosis is often due to prolonged constipation, and constipation process often take some laxatives, such as intestinal clear tea or senna, etc., can lead to pigmentation, resulting in a change in the color of the stool, most of the dark red, brown or brown, is caused by hyperpigmentation. Generally this situation, or first pay attention to improve the symptoms of constipation, can be appropriate to give lactulose oral solution, bifidobacterium capsules and other symptomatic treatment, and at the same time discontinue some of the relevant laxatives, because this type of laxative is caused by intestinal pigmentation is a decisive factor. Therefore, improving gastrointestinal function and paying attention to physical exercise are the preferred methods to solve the problem of colorectal melanosis.