The professional name of brain pacemaker implantation surgery is Deep Brain Stimulation (DBS for short.) In 1987, Prof. Benabid of France reported a study that electrical stimulation of the Vim nucleus of the thalamus could effectively treat the tremor symptoms of patients with Parkinson’s disease, thus formally initiating the precedence of brain pacemaker treatment for Parkinson’s disease, which has been in development for nearly 30 years now. Brain pacemakers can control the movement disorder symptoms of Parkinson’s disease patients, such as: tremor, rigidity, slow movement, etc.; at the same time, it can also reduce the duration and severity of the anisotropic symptoms caused by the long-term use of levodopa drugs, reduce the fluctuation of the symptoms; it can also reduce the dosage of levodopa drugs. In conclusion, brain pacemaker therapy can effectively control the symptoms of dyskinesia through long-term electrical stimulation of the motor nuclei of the brain, and improve the patient’s daily life ability and quality of life. So when is the right time to implant a brain pacemaker? It is critical to know when a person with Parkinson’s disease may choose to undergo brain pacemaker implantation. Generally speaking, Parkinson’s disease patients take medication initially with very good results, known as the “honeymoon period” of the medication. However, as time progresses, after the “honeymoon period”, patients will find that the effectiveness of the medication is gradually weakened, and even if the dosage is increased, it will not be able to achieve the satisfactory effect of the medication taken at the beginning of the disease. In addition, long-term use of levodopa drugs will also appear some drug-induced specific complications, such as the “switch” phenomenon, anisotropy and so on. This is the best time to undergo pacemaker implantation. Of course, the decision as to whether a patient is a good candidate for pacemaker implantation must be made after a detailed evaluation by an experienced specialist (functional neurosurgeon, neurologist) who will weigh the pros and cons of the procedure. Currently, it is believed that patients who have experienced a decrease in the efficacy of medications or motor complications, but whose balance, speech, and cognitive function have not been significantly affected, are better candidates for pacemaker implantation, and the effects of the procedure are more long-lasting. If pacemaker implantation is performed too late, the results are limited and the risks of surgery are increased.