Six key points are important for the effectiveness of brain pacemaker surgery: 1) clear diagnosis of Parkinson’s disease; 2) correct target selection; 3) precise electrode placement; 4) appropriate programmed parameter combinations; 5) reasonable combination therapy of Parkinson’s disease medications; and 6) appropriate timing of brain pacemaker surgery. Parkinson’s disease symptoms are complex and varied, easy to misdiagnose, only primary Parkinson’s disease is an indication for surgery, but also to do a good job of preoperative examination and preparation, including recent brain MRI, general examination and psychocognitive function assessment, etc., and preoperative discussions with neurologists and psychiatrists. As a surgeon, what is important is ‘precise implantation’ and ‘exquisite technique’. The size range of the deep brain nuclei is often only a few millimeters, the electrode must be precisely implanted in the target target point in order to play a therapeutic role, deviation from the target point will not only fail to achieve the therapeutic effect, but will also bring side effects. Brain pacemaker implantation surgery process has many links, interlocking, one link is not good, will affect the next link, thus affecting the accuracy of the entire operation, requiring the surgeon must have a solid knowledge of neuroanatomy, electrophysiology and exquisite surgical operation techniques. In addition, post-surgical program control is also an important part of brain pacemaker therapy for Parkinson’s disease patients, which also requires the program control doctor to have a solid and profound foundation of relevant professional knowledge and follow the principle of obtaining the greatest improvement of clinical symptoms with the smallest stimulation intensity and the smallest dose of drugs.