Brain pacemaker is a common term for deep brain electrical stimulation, which was pioneered by French scholar Benabid in 1987. After more than 30 years of clinical application, it has been proven that brain pacemaker therapy has good effects, and is not only applied to Parkinson’s disease, but also applied to the treatment of a variety of disorders including idiopathic tremor, spastic strabismus, torsion spasms, and Meijer’s syndrome. Brain pacemakers are minimally invasive, safe, and can comprehensively improve symptoms such as limb tremor, rigidity, bradykinesia, and postural gait in patients with Parkinson’s disease, and as limb symptoms progress and worsen, they can continue to achieve good improvement by adjusting parameter values in vitro. In addition to this, there is a fallback that does not interfere with new future treatments. However, brain pacemaker therapy is not suitable for every patient, and the success of the surgery needs to meet the timing of the surgery, preoperative detailed examination and evaluation, precise positioning during the surgery, postoperative program control and drug adjustment, rehabilitation and other factors. 1, the timing of surgery: too early, the patient to the drug efficacy, too late, the patient may lose the significance of surgery. Therefore, the timing of surgery is very important, and it is now believed that Parkinson’s disease patients in the gradual decline in drug efficacy, that is, taking anti-Parkinson’s disease drugs in the peak concentration of efficacy is ideal, but the efficacy of the drug will soon subside or adverse reactions, such as the “switch” phenomenon, anisotropy, freezing phenomenon, that the disease has begun to affect the normal work and life, and stimulation of the brain. Accepting brain pacemaker treatment can get obvious therapeutic effect, and the possibility of recovering normal living ability and working ability after surgery is much greater than that of patients with advanced Parkinson’s disease. Correct preoperative evaluation and diagnosis: If the type of disease is not judged accurately, it will have a great impact on the postoperative prognosis, and may lead to two completely different directions of efficacy. Therefore, the diagnosis of primary Parkinson’s disease, is the indication for surgery patients. After the patient is hospitalized, detailed physical examination, no serious physical disease and obvious intellectual disability, serious mental illness, before surgery can be considered. Precise surgical positioning: accurate targeting is the basis for the efficacy of postoperative treatment. As the saying goes, “a tiny lapse can lead to a huge difference”, the size of the deep brain nuclei is often only a few millimeters. The pacemaker implantation procedure has many interlocking links, and if one link is not done well, it will affect the next link, thus affecting the accuracy of the whole procedure. Therefore, the surgeon is required to have solid and profound knowledge of neuroanatomy and electrophysiology, exquisite surgical operation techniques and good psychological quality to deal with various accidents. 4. Reasonable stimulation mode setting and drug selection: it is the key to whether or not the therapeutic effect of deep brain electrical stimulation can be brought into play to the best and the greatest. It is also required that the program control doctors have solid and profound related professional knowledge, and follow the principle of obtaining the maximum improvement of clinical symptoms with the minimum stimulation intensity and the minimum drug dosage. 5, appropriate psychological counseling and rehabilitation therapy: positive and optimistic attitude is conducive to the treatment of Parkinson’s disease, psychological counseling is conducive to the improvement of the disease, the role of rehabilitation exercise is not only to enhance physical fitness, increase resistance, but also in order to prevent the joints from becoming deformed.