Brain pacemaker, also known as Deep Brain Stimulation (DBS), is a treatment that implants electrodes in specific neural nuclei in the brain and releases high-frequency electrical stimulation to inhibit the electrical impulses of these over-excitable neurons due to the reduction of dopaminergic neurons, reducing their over-excitable state, thus reducing the symptoms of Parkinson’s disease, and treating and relieving the three main symptoms of Parkinson’s disease: tremor, stiffness, and bradykinesia, and particularly improving midline symptoms such as difficulty in starting and turning over. midline symptoms such as difficulty in starting and turning over. Scope of application of DBS surgery for Parkinson’s disease 1. Primary Parkinson’s disease, taking levodopa used to be effective. 2. The efficacy of the medication has gradually decreased or side effects have appeared. 3, The disease has begun to seriously affect the normal working life. 4. There is no clear intellectual disability, and the cooperation between surgery and follow-up is good. 5, Test stimulation during or after surgery can effectively control the lower symptoms. Of course DBS technique can also treat functional disorders such as idiopathic tremor, torsion spasms, Meijer’s syndrome, obsessive-compulsive disorder, severe depression, anorexia nervosa, Tourette’s syndrome and others. The procedure consists of the following steps The surgical procedure for DBS is divided into the following steps: 1. Installation of the stereotactic head frame The stereotactic head frame helps the neurosurgeon to determine where to place the electrodes. Local anesthesia is used for this procedure, and there is usually no significant discomfort except for a mild sensation of pressure. Precise positioning The position of the orienting frame is checked by CT or magnetic resonance imaging (MRI) and, if necessary, helps the doctor to obtain the localization data of the implanted brain pacemaker site. Implantation of electrodes After locating the stimulation site according to the previous positioning, the electrodes are placed into the brain. The damage caused by this procedure is minimal, and since the brain itself has no pain sensation, no pain is felt. After implanting the electrodes, the doctor will conduct a preliminary test. First let the patient do some simple movements, such as holding a cup, stretching the arms, drawing spirals, etc. Then, according to the patient’s feelings and the degree of improvement of the symptoms, the position of the electrodes and the stimulation intensity will be further adjusted in order to achieve the best results. 5. Implant the whole system If the symptoms are controlled during the test, the doctor can further implant the whole brain pacemaker system. This procedure can be done immediately or after several days of observation. The procedure involves implanting a pulse generator under the skin of the chest and connecting the pulse generator to the electrodes via a guide under the skin. The patient is awake most of the time during the procedure, as the patient’s cooperation is needed to determine the position of the electrodes and the effectiveness of the treatment. Post-operative follow-up is very important. After the wound has healed, the surgeon uses computerized telemetry to regulate the pulse generator outside the body, which is also a painless procedure.