Rheumatoid factor 22IU/ml is higher than the upper limit of the normal reference value, the patient should further improve the relevant auxiliary examination to clarify the cause of the abnormal rheumatoid factor, and if necessary, targeted drug treatment, surgical treatment and other treatments. Rheumatoid factor is one kind of autoantibodies in human body, under normal circumstances, it should be between 0~20IU/ml or negative, while 22IU/ml is slightly higher than the upper limit of the normal reference value. Elevated rheumatoid factor is most commonly seen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, desiccation syndrome, dermatomyositis, scleroderma and other diseases such as hepatitis, mononucleosis, schistosomiasis and tuberculosis. In addition to this, elevated rheumatoid factor is also seen in blood samples of the elderly. Therefore, patients should undergo further auxiliary tests such as blood sedimentation, CRP, other autoantibodies, ultrasound, CT, etc., and combine them with the patient’s clinical manifestations in order to identify the cause of the abnormal rheumatoid factor. If necessary, medication, surgery and other treatments should be targeted. Laboratory test results should be interpreted by a professional physician, and it is recommended that patients with a rheumatoid factor of 22IU/ml go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.