Tiredness and inability to sleep are considered to be related to excessive mental stress, bad lifestyle habits, disease factors, etc. 1. Excessive mental stress: it will cause the biological clock to be out of order, which will have an impact on sleep, resulting in the inability to fall asleep, etc.. It is important to maintain a relaxed mood and relieve the pressure of life and work. 2. Bad habits: If you drink coffee, strong tea, cola, etc. before going to bed, it will also cause sleeplessness, such as strong tea contains tea polyphenols and other caffeine-like components, which can excite the central nervous system, and has the effect of refreshing and waking up the brain, which will aggravate the symptoms of insomnia after insomniacs drink it. 3. Disease factors: some diseases can cause physical pain, such as tumors, surgical treatment, pain can cause patients to sleep; mental illness, such as anxiety and depression, can also lead to fatigue and can not sleep. Feeling very tired but can not sleep if the adjustment of lifestyle habits did not improve, should be alert to the possibility of pathological causes, it is recommended to timely hospital consultation, under the guidance of the doctor to identify the causes and give treatment.