Most consideration of a stiff face that does not smile is a lesion of the extrapyramidal system. In the case of middle-aged and elderly people, it may be Parkinson’s disease, which is a neurodegenerative disease with lesions mainly involving the extrapyramidal system. In the early stage, resting tremor may occur, and as the disease worsens, increased muscle tone may appear, and patients may exhibit facial rigidity or limb stiffness, and may have motor retardation, and in the late stage, postural gait abnormalities may appear, and patients may have a panicked gait. There is no specific treatment available. Methotrexate and benadryl controlled-release tablets can be applied, and if the tremor is severe, oral benzodiazepines can be administered, etc. If the patient is young, he may have hepatomegaly, which is a disorder of copper metabolism. Patients may have signs and symptoms of extrapyramidal system, may have abnormal liver function, and may have corneal KF ring, which can be treated with oral amantadine. It may also be caused if the patient applies medications, common drugs such as phenothiazines may be present, and if the patient is older than 75 years old, it may also be caused when applying metoclopramide.