The reason for not drinking alcohol while taking penicillin V potassium tablets is as follows: 1. Alcohol can cause allergic reaction to penicillin and can increase skin sensitivity, so drinking alcohol while taking penicillin V potassium tablets can induce edema in the larynx, and in serious cases, respiratory depression and respiratory distress, which can be life-threatening. 2. 3. Penicillin V potassium tablets need to be metabolized by the liver, and alcohol also needs to be metabolized by the liver, which will increase the burden on the liver and induce changes in liver function, and even serious heavy alcohol abuse may cause liver failure.