Diseases that cause high anti-beta2-glycoprotein 1 antibodies mainly include autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis, as well as conditions such as habitual miscarriage, thrombotic states, and atherosclerosis, which can also cause high beta2-glycoprotein 1 antibodies. Anti-β2-GP1 antibody is the main antibody leading to antiphospholipid antibody syndrome, which is closely related to pregnancy-related diseases and may be involved in the occurrence of miscarriage. It can cause multiple infarcts and vasoconstriction of placental blood vessels, reduction of blood flow to the placenta, and thrombosis, which can lead to miscarriage and stillbirth. It can also inhibit the production of prostaglandin I2 in fetal vascular endothelial cells, leading to fetal circulatory disorders and miscarriage. It can directly bind to phospholipids on the surface of trophoblast cells, causing destruction of trophoblast cells, which can lead to miscarriage and stillbirth.