Dipyridamole and sartans are mainly used in the treatment of hypertension and are usually used together when the condition requires it. Dipyridamole refers to dihydropyridine calcium channel blockers, mainly by blocking calcium channels, so that the concentration of intracellular calcium ions to reduce, thereby inhibiting the contraction of cardiac muscle and vascular smooth muscle, so that the blood pressure decreased. Clinically, it is mainly used in the treatment of hypertension and angina pectoris. Sartans refer to angiotensin 2 receptor antagonists, and the mechanism of action is by blocking the action of angiotensin, so that vasodilatation and blood pressure drop. Clinically, they are mainly used in the treatment of hypertension. Dipyridamole and sartans have different mechanisms of action, and the combination of drugs can produce synergistic effects, which can be used in patients with hypertension that is not well controlled by a single drug, and sartans can also reduce the risk of peripheral edema produced by dipyridamole, so they can be used in combination, but they should also pay attention to their adverse reactions. Adverse effects of diphenhydramine include peripheral edema, hypotension, headache, chest pain, redness of the face, palpitations, etc. Abdominal pain, diarrhea, nausea and constipation may also occur. It is contraindicated in people who are allergic to the components of the drug, in patients with cardiogenic shock, up to 20 weeks of pregnancy, as well as in breastfeeding women. Adverse reactions to sartans include headache, dizziness, nausea, vomiting, abdominal pain, diarrhea, fatigue, flu-like symptoms. It is contraindicated in people who are allergic to the components of the drug, in patients with severe liver damage, in pregnant women from 4 to 9 months. Use with caution in patients with severe renal insufficiency or bilateral renal artery stenosis, which may cause renal failure. When diphenhydramine is used in combination with sartans, it should be used under the guidance of a specialist, and if there is any discomfort, go to the hospital in time.