Stone bone disease is also known as marble bone, primary brittle osteosclerosis, sclerosing proliferative bone disease and chalk-like bone. It is a rare disorder of bone development. It was first discovered by Albers-Schonberg (1904) and is also known as Albers-schonberg disease. The disease is characterized by the persistence of calcified cartilage, which causes extensive osteosclerosis and, in severe cases, the closure of the greater marrow cavity, resulting in severe anemia. The disease is often familial, with the majority of cases being recessive. The cause of stone bone disease is unknown and may be related to genetic factors. It is thought to be due to an apparent lack of normal osteoblasts or functional defects, with the main change being excessive calcification of bone-like tissue and lack of true ossification, resulting in slow resorption of calcified cartilage matrix and primitive trabeculae, resulting in a lack of bone plate layer and osteoblasts in the bone, loss of elasticity, and poor trabecular structure, making the bone brittle and easily broken. Due to the presence of a large amount of calcified cartilage matrix, the bone marrow cavity is significantly reduced or even occluded, and the bone cortex and cancellous matter are hardened, and the two cannot be distinguished from each other. Bone cortical hyperplasia and dense bone cancellous appear as characteristic changes in the whole body skeletal X-ray. As the bone marrow cavity is filled with a large amount of calcified matrix, the hematopoietic tissues are significantly reduced and extra-marrow hematopoietic organs such as liver, spleen and lymph nodes are enlarged, resulting in myeloid non-functional anemia. Long-term anemia leads to stunted growth and poor nutrition. Because the calcium in the bone cannot be transported to the bone growth site normally, rickets is likely to occur in infancy and early childhood, and may cause spontaneous fractures. The CT signs of hydrocephalus, subdural effusion or ventricular dilatation occur due to sclerosis and hyperplasia of the skull and narrowing of the holes at the base of the skull, resulting in obstruction of cerebrospinal fluid flow. The mortality rate is up to 70% or 80% within one year of age. Patients will suffer from facial palsy, anemia, developmental delay, resulting in blindness and deafness, inability to lift their heads, stand, walk or speak, and basically cannot live beyond childhood if they do not receive proper treatment. Young men and women should know the family history of both parties before marriage and practice eugenics.