It is often said that growth hormone will promote the growth of bone age, in fact, this view is obviously a misunderstanding. 2007, the United States, Europe, Asia-Pacific and other major global children’s endocrine society of the main experts in the Mexican meeting to reach a consensus: the normal dose of growth hormone does not promote the growth of bone age and sexual development. The reason why some people have such a view is mainly due to one-sided understanding. Growth hormone is more used in growth hormone deficiency in children, such children, bone age is often low, the application of growth hormone to make growth hormone basic normal, behind the bone age has a tendency to normal bone age, easy to mistakenly think that is to promote the growth of bone age, there are a lot of application of growth hormone in children, has entered puberty, puberty, the rapid growth of bone age is easy to mistakenly think that is caused by growth hormone. Because of the medication period, any problems are easy to consider towards the drug effects. Currently there is enough evidence to show that boys using aromatase inhibitors (because girls are not suitable for use, easy to cause boyish) so that androgens can not be converted to estrogen, bone age can be almost do not grow (due to not yet officially approved, not yet used in the clinic, but only used for scientific research), but the amount of aromatase inhibitors do not inhibit growth hormone secretion, and inhibit growth hormone secretion, unlike the gonadotropin-releasing hormone tip analogs (GnRHa), and inhibit growth hormone. growth hormone secretion, and inhibit growth hormone receptor sensitivity. This suggests that bone age growth is primarily related to estrogen (which is present in boys as well). Besides, growth hormone is often combined with gonadotropin-releasing hormone spiking analogs (GnRHa) to treat true precocious puberty, which would not be used in precocious puberty treatment if it would significantly promote bone age growth. There are also patients with gigantism, that is, growth hormone secretion disorder, generally there is no precocious maturation or early closure of the bone age phenomenon, if growth hormone to promote the growth of bone age, patients with gigantism can not become giants. And if growth hormone can significantly promote bone age growth, it can not be used to increase lifetime height, the FDA will still approve the use of it to increase lifetime height? Would so many people still pay so much for long-term use?