If jaundice rebounds after artificial liver therapy, medications should be taken to protect the liver and antiviral therapy as prescribed by the doctor, and liver transplantation should also be considered. If jaundice rebounds after artificial treatment, medications such as silymarin and adenosylmethionine may be prescribed to protect the liver, and a liver transplant may be considered if a liver source is actively sought. Artificial liver therapy refers to the use of chemical devices, extracorporeal machinery, or biological devices to replace the function of the liver, which can help to treat jaundice caused by liver failure, and commonly used techniques include plasma exchange and hemoperfusion. However, this type of treatment can only temporarily or partially replace liver function, and may cause allogeneic rejection, so regular review is still needed after treatment.