Vulvar hyperplastic moss generally refers to vulvar white lesions, which are pigmented changes in the vulva of women, and the symptoms are mainly manifested as vulvar itching and mossy changes. The symptoms are mainly itchy and mossy. Clinically, the symptoms can be relieved through standardized treatment with medication. Vulvovaginal leukoplakia is a chronic disease in which the skin and mucous membranes of the vulva are pigmented. The cause of the disease is not clear, and may be related to self-stimulation, heredity, infection, endocrine and other factors. Patients mainly manifested as vulvar itching, mossy changes and other symptoms, some patients also have blood in the stool, anal fissure and so on. For the treatment of vulvar leukoplakia, patients can follow the doctor’s instructions to apply topical corticosteroid drugs, such as 0.025% fluoxetine ointment, 0.01% tretinoin ointment and so on. Topical immunosuppressant treatment, such as tacrolimus ointment, can also be applied. With the above treatments, the discomfort can usually be relieved, but not cured. Patients with vulvar leukoplakia are advised to seek prompt medical attention and standardized treatment. Patients must follow the doctor’s instructions to use the full amount of medication, full course of treatment, can not stop without authorization, so as to avoid the condition of the delayed cure.