Genetic factors play an important role in the development of schizophrenia. Studies have shown that the risk rate for first-degree relatives with the same disease is about 4-14%, about 10 times that of the general population. If both parents have schizophrenia, the risk rate can be as high as 40%. The risk rate among second-degree relatives of patients is about three times higher than that of the general population. Foreign studies (1974) have shown that monozygotic twins of schizophrenia have a higher rate of homozygosity than dizygotic twins. Monozygotic twins had a homozygosity rate of 6%-73%; dizygotic twins had a homozygosity rate of 2.1%-12.3%. Studies have shown that schizophrenia has a genetic component, and the closer the blood relationship, the higher the risk rate; genetic factors have a greater impact than environmental and other factors. As of now, studies on the genetic localization of schizophrenia are inconclusive, and schizophrenia may be polygenic, resulting from the superposition of several genes.