The disease has a variety of symptoms and is often confused with many gastrointestinal, respiratory and ear, nose and throat diseases, making it easy for not only patients but also doctors to overlook the possibility of GERD, leading to misdiagnosis and mistreatment. Depending on the stage of development of the disease, the following symptoms may occur in general. Gastroesophageal stage: The lesions caused by reflux in this stage are mainly in the esophagus, and the most common symptoms are heartburn and acid reflux. Heartburn is a burning sensation that the patient feels in the anterior chest area and heart fossa. Acid reflux is when the patient feels a rush of acid coming up from the abdomen into the mouth in the absence of nausea, vomiting, etc. In addition, some patients may have chest pain, chest tightness, and indigestion. Pharyngeal phase: When the reflux is aggravated and lesions appear in the upper esophagus and pharynx, patients will have symptoms similar to acute and chronic pharyngitis, most typically an unexplained chronic cough, usually dry, and patients are often treated repeatedly in respiratory or ENT departments without significant improvement, while some patients develop recurrent nocturnal coughs that interfere with rest. Patients may also experience discomfort such as tingling in the throat, foreign body sensation, and sore throat. Oral-nasal phase: When the reflux is further aggravated, the oral, nasal and middle ear mucosa becomes diseased, and patients may experience symptoms such as runny nose, sneezing, nasal congestion and tinnitus, which may even lead to otitis media. Laryngotracheal stage: When the regurgitant enters the trachea, it will cause symptoms such as coughing, coughing, shortness of breath and breath-holding. There are many patients whose symptoms are very similar to asthma attacks, but they receive asthma treatment in the respiratory department with poor results. When the disease progresses to this stage, it is already more serious and can lead to a significant decrease in the patient’s quality of life and even life-threatening laryngospasm.