High glutamyl transpeptidase may be a normal physiological phenomenon of the body, but it can not be ruled out that it is caused by pathological changes in the liver, drug factors and other reasons. 1. Physiological factors: glutamyl transpeptidase in the clinic generally refers to γ-glutamyl transpeptidase, which exists in hepatocytes, and the γ-glutamyl transpeptidase in human serum mainly comes from the liver. If there are late nights, irregular eating habits, alcohol consumption, overwork, etc., γ-glutamyl transpeptidase may be physiologically elevated. 2. Liver disease: γ-glutamyl transpeptidase is a sensitive indicator of pathological changes in the liver. When liver inflammation, cirrhosis, alcoholic hepatitis, fatty liver, etc. exists, due to the necrosis of liver cells, γ-glutamyl transpeptidase will be released into the bloodstream, and γ-glutamyl transpeptidase will be elevated. 3. Drugs: Since drugs are mainly metabolized in the liver, long-term use of certain drugs such as birth control pills, phenobarbital, antipyrine and so on, may lead to gamma-glutamyl transpeptidase elevation. If γ-glutamyl transpeptidase is elevated, it is recommended to go to a regular hospital for consultation and treatment under the guidance of a professional doctor.