Dry syndrome usually does not need to check anti-double-stranded DNA antibody, if you want to make a differential diagnosis of the disease, you need to check anti-double-stranded DNA antibody, dry syndrome usually need to check anti-SSA antibody, anti-SSB antibody and so on. Dry syndrome is a chronic inflammatory autoimmune disease that mainly involves a variety of exocrine glands, and clinically it mainly manifests as dryness of the mouth and eyes. Autoantibody tests for patients with dry syndrome include rheumatoid factor, anti-SSA antibody, anti-SSB antibody, etc., and anti-double-stranded DNA antibody is usually not checked. Anti-double-stranded DNA antibody is a serologic marker of systemic lupus erythematosus, which needs to be differentiated from systemic lupus erythematosus in the diagnostic process of dry syndrome, so it is necessary to check anti-double-stranded DNA antibody. Tests for patients with dry syndrome also include lacrimal gland function tests, salivary gland function measurements, and lip gland biopsies. It is recommended that patients suspected of having dry syndrome go to the hospital in time to improve the examination and active treatment to avoid delay.