The presence of granulation tissue is not necessarily Crohn’s disease. Intestinal tuberculosis usually also shows granulation, which is differentiated based on whether it is a caseous necrotizing granuloma. Crohn’s disease is also known as segmental enteritis and granulomatous enteritis, but it is not necessary that granulomas in the intestines are Crohn’s disease. The granulomas of Crohn’s disease are non-caseous necrotizing granulomas, which are prevalent in the terminal ileum and the right half of the colon. The main manifestations are abdominal pain, diarrhea, intestinal obstruction, accompanied by fever, nutritional disorders and other symptoms. The clinical presentation, enterography and endoscopy of intestinal tuberculosis are very similar to Crohn’s disease. Intestinal tuberculosis occurs anywhere in the gastrointestinal tract, with the ileocecal region being the most common, and patients are equally likely to present with a range of symptoms such as abdominal pain, diarrhea loss of appetite, and night sweats, with caseous necrotizing granulomas being the main differentiator between intestinal tuberculosis and Crohn’s disease. If you find the appearance of granulomatous tissue, it is recommended to ask your doctor in time.