Alzheimer’s disease is a syndrome of progressive decline in cognition and mobility caused by degenerative changes in the central nervous system. Symptoms before death mainly include loss of self-care ability, memory loss, behavioral abnormalities and multi-organ failure. 1. Inability to take care of oneself: unable to do any thing independently in life, e.g. going to the toilet, eating, etc. 2. Loss of memory: Cannot remember everything, even do not know who they are. 3. Abnormal behavior: often do things that are not under the control of the brain, often without knowing it. 4. Failure of multiple organ involvement before death, e.g., respiratory failure, heart failure, kidney failure, etc., which eventually leads to death. If you find similar symptoms in the elderly at home, you should seek medical advice promptly.