Petechiae on the conjunctiva are one of the clinical manifestations of sepsis. The clinical onset of sepsis is rapid, and the rash takes the form of petechiae, urticaria, pustular rash, and scarlet fever-like rash with petechiae on the conjunctiva. Gram-negative coccus sepsis can cause petechiae on the conjunctiva. The following diseases are also causes of petechiae on the conjunctiva: 1. Sepsis A systemic infection caused by the invasion of pathogenic bacteria into the bloodstream, where they grow and multiply, producing toxins, and occurring easily when the body’s resistance is reduced. Clinically, it mainly manifests as chills, high fever, toxemia symptoms, rash, arthralgia, hepatosplenomegaly, infectious shock, migratory lesions, etc. It is divided into Gram-positive coccus sepsis, Gram-negative bacillus sepsis and septic sepsis. The vast majority of cases have an acute course, are severe and have a poor prognosis. Today, sepsis is further considered to be a chain reaction process caused by the entry of pathogenic bacteria, their toxins and metabolites into the bloodstream and the activation and release of inflammatory mediators. This process, in clinical terms, can lead to dysfunction and failure of multiple organs throughout the body. That is, not only the state of the presence of pathogenic bacteria in the organism is seen, but also the immune response of the organism and its consequences are valued. The known mediators of inflammation are complement components, arachidonic acid metabolites, tumor factors (TNF), interleukins (IL-s), interferons (IF-a), platelet-activating factor (PAF), pre-macrophage inflammatory cytokines (MPIC), proteases, coagulation oxidants and oxygen free radicals. Antibiotic therapy is the mainstay, supplemented by other treatments. Preventive measures are to avoid damage to the skin mucosa and to prevent bacterial infection. 2, subacute infective endocarditis Subacute infective endocarditis often occurs on the basis of heart disease such as rheumatic heart valve disease, ventricular septal defect, arteriovenous insufficiency, etc., and can also occur in people without heart disease. The main pathogens are bacteria, followed by fungi, rickettsia, chlamydia and viruses. The main manifestations are low to moderate fever, progressive anemia, malaise, night sweats, hepatosplenomegaly, pestle-like fingers (toes), and vascular embolism may occur, with more young adults. In recent years, there has been an increase in the incidence of the disease based on mitral valve prolapse, cardiac catheterization and cardiac surgery, as well as age-related degenerative valve disease, with a gradual increase in the age of onset. Streptococcus straw green is the most important causative agent of the disease, but in recent years has been significantly reduced, a variety of staphylococci, hemolytic streptococci, enterococci and Gram-negative bacteria have become the main causative agent. 3, gonococcal conjunctivitis Gonococcal conjunctivitis is an extremely violent acute purulent conjunctivitis, highly contagious and can seriously endanger vision. It is characterized clinically by highly congested and edematous eyelids and conjunctiva, with large amounts of purulent secretions, and if left untreated, corneal ulceration and perforation can occur within a short period of time. 4. gonococcal conjunctivitis Gonococcal conjunctivitis, also known as gonorrheal eye or gonorrheal pus leaky eye, is an extremely intense acute purulent conjunctivitis. The disease is characterized by a high degree of eyelid and conjunctival congestion and edema and a large amount of purulent discharge, and if not treated promptly, corneal ulceration and perforation will occur within a short time, leading to serious consequences of blindness. After liberation, with the control of STD, this disease has been extremely rare in China. However, in recent years, gonorrheal genitourinary infection has been increasing year by year in China.