Extraocular muscle weakness is a disorder of extraocular muscle movement due to various factors, muscle weakness, commonly seen in sarcoidosis, pediatric myasthenia gravis, progressive myotonic dystrophy, etc. There is a certain deficiency of qi and blood and lack of vitamins causing the problem. There may also be a relationship with loss of tendon support, lack of sleep, and congenital defects. The following diseases are also causes of extraocular muscle movement weakness: 1, ophthalmic myasthenia gravis Myasthenia gravis (MG) is a chronic autoimmune disease that involves acetylcholine receptors in the postsynaptic membrane at the nerve-muscle junction, resulting in impaired excitation transmission between nerves and muscles, with a tendency to recur and remit. 2, neurological food poisoning Botulism is an acute poisoning disease caused by eating food containing Clostridium botulinum exotoxin. The disease was first discovered in 1793 in Wildbad, southern Germany, after eating spoiled salami, and was named botulism. In recent years, four clinical types of botulism have been proposed: ingestion botulism, infant botulism, traumatic botulism, and inhalation botulism. All of them have neurological symptoms as the main clinical manifestation, and the morbidity and mortality rate is high. 3, progressive myodystrophy Progressive myodystrophy (progressive myodystrophy) is a group of primary skeletal muscle diseases caused by genetic factors, its clinical manifestations are mainly slowly progressive muscle atrophy, muscle weakness and varying degrees of motor impairment. The disease can be caused by a variety of genetic modalities, and its clinical manifestations have different characteristics, resulting in many types. This section provides an overview of the major types.